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Azoospermia |
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| 1. |
What is azoospermia ?
Azoospermia is the term used when there is a complete absence of sperm in the ejaculate. Most patients assume that this diagnosis would rule out the possibility of his ever conceiving a child.
Azoospermia is called when there is no sperm in semen. This type of semen disorder is found in approximately 3% of infertile men i.e. absent sperm.
You should know that testis has two separate functions
(i) Production of normal sperms in semen which needed for pregnancy & normal fertility.
(ii The other function of testis is production of male hormones i.e. testosterone & others. So in most patients with nil sperms though semen has absent sperms still production of male hormones remains normal.
How sperms develop: When boy becomes of 14 years of age then L.H. & F.S.H. hormone secretion from pituitary increases. The rise in these hormones leads to proliferation of sperm forming cells (Germ Cells) in the testis. These germ cells start multiplying under the effect of above-mentioned pituitary hormones along with assistance of other hormones as testosterones, Growth hormones, Androstenidione, insulin like growth factor-I, Thyroids hormone, paracrine hormone & growth factors. Under the control of above-mentioned hormones germs cells divide & transformed into primary spermatocytes. Then further maturation of primary spermatocytes to spermatids & then finally into mature spermatozoa (i.e. normal sperms) occurs under the control of above-mentioned hormones. After few weeks of progressive maturation inside the testis these sperms become normally motile & develop the capacity to fertilize the ovum. This total sperm cycle, from first stage to final stage of normal mature sperms is of three months. Thus to produce normal sperms testis should have normal sperm producing germ cells & normal regulating hormones. Any major hindrance in the development of these spermatozoa will lead to absent sperm production resulting into nil sperm.. |
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| 2. |
What Are The Causes of Azoorpermia?
The various causes of Azoospermia are as follows :
Hormone disorder : The various endocrine (Hormone) disorder leading to azoospermia are as follows
| 1. |
Hormone deficiency of pituitary gland as L.H., F.S.H., Prolactin, thyroids hormone, hypothalmic deficiency of GnRH, Pituitary gland failure, Hypopituitarism, Idiopathic hypopituitarism, Kallman syndrome, Isolated hypogonadotropic hypogonadism, Drugs, toxins, Idiopathic hypogonadotropic hypogonadism & due to many more causes. |
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| 2. |
Obstruction in the outflow of semen (Sperms) from testis to outside through urethral opening. Many times the production of sperms in testis is absolutely normal but these sperm are unable to come out due to obstruction in the out flow tract leading to absent sperms in the semen. The various causes of obstruction are absent vas deferens, absent seminal vesicle, posttraumatic, post surgical ligation of vas deferens. After some infections, as chlamydial, gonococcal urethritis. It may also be due to post tubercular epididimo-orchitis. The sperm may also not come out of testis if the are imotile due to any of the following causes as imotile cilia syndrome, kartagener syndrome cystic fibrosis & many other rare diseases. |
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| 3. |
Absence of germ cells in testis also called sertoli cell only syndrome. In this there are no germs cells i.e. sperm forming cells in the testis. For you knowledge, I wish to inform you that in testis germ cell come to testis from neural cord area of the body during neural cord area of the body during development of fetus. So in some fetuses this migration of sperm cells do not occurs leading to testis only having testosterone forming & sertoli cells. Thus this condition is called sertoli sell only syndrome it is a developmental defect. |
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Maturation Arrest (. Spermatid arrest): of primary spermatocytes to secondary spermatocyte, spermatids or to mature spermatozoa. Due to may local, systemic, hormonal growth factor deficiency or due to idiopathic factor. The various paracrine hormones and growth factors are essential for normal development i.e. maturation of one germ cells to multiplication of ultimately production of multiple mature, normal & motile sperms. Many other factor as infection, varicocele, drugs, chemotherapy may also lead to maturation arrest. The other causes may by developmentally defective germs cells & spermatocyte. So that they did not have inherent capacity of developing into a mature & motile sperms.
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Testicular disorders (primary leydig cell dysfunction), Chromosomal (Klinefelter syndrome and variants, XX male gonadal dysgenesis), Defects in androgen biosynthesis, Orchitis (mumps, HIV, other viral, ),Myotonia dystrophica, Toxins (alcohol, opiates, fungicides, insecticides, heavy metals, cotton seed oil), Drugs (cytotoxic drugs, ketoconazole, cimetidine, spironolactone) |
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Varicocele (Grade 3 or more severe): A varicocele is a varicose vein in the cord that connects to the testicle. (A varicose vein is one that is abnormally enlarged and twisted.)
Varicocele decreases sperm productions by elevating temperature of the testis, may produce higher levels of nitric oxide chemical in the testis which blocks sperm production, varicocele damages sperms directly & lastly varicocele decrease the oxygen supply to testis. |
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Drugs (e.g. spironolactone, alcohol, ketoconazole, cyclophosphamide, estrogen administration, sulfasalazine) |
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Presence of Antisperm antibody. These Antisperm antibodies bind with sperms & either make them less motile, totally immotile or even dead which is called necrospermia. |
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Trauma |
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Environmental toxins |
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Viral orchits |
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Granulomatous disease as tuberculosis, sarcoidosis of the testis |
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Defects associated with systemic diseases, Liver diseases, Renal failure, Sickle cell disease, Celiac disease |
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Neurological disease as myotonic dystrophy |
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Development and structural defects, Germinal cell aplasia, sertoli cell only syndrome, Cypt-orchidism |
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Androgen resistance |
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Mycoplasma infection |
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Cystic fibrosis patients often have missing or obstructed vas deferens (the tubes that carry sperm) and hence a low sperm count. |
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Klinefelter syndrome patients carry two X and one Y chromosomes (the norm is one X and one Y), which leads to the destruction of the lining of the sperm forming germ cell in the testis. |
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Environmental Assaults: Over exposure to environmental assaults (toxins, chemicals, infections) can cause nil sperm either by direct suppression of sperm production or on the hormone. Some chemicals that affect sperm production men are: Oxygen-Free Radicals, Estrogen emulation pesticidal chemicals (DDT, aldrin, dieldrin, PCPs, dioxins, and furans), plastic softening chemicals like Phthalates, hydrocarbons (ethylbenzene, benzene, toluene, and xylene) |
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| 21. |
Exposure to Heavy Metals: Chronic exposure to heavy metals such as lead, cadmium, or arsenic may affect sperm production and may cause nil sperms in otherwise healthy men. Trace amounts of these metals in semen seem to inhibit the function of enzymes contained in the sperms, the membrane that covers the head of the sperm. |
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| 22. |
Radiation Treatment: Over-exposure to radiation & xrays affect any rapidly dividing cell, so cells that produce sperm are quite sensitive to radiation damage. Cells exposed to significant levels of radiation may take up to two years to resume normal sperm production, and, in severe circumstances, may never recover. |
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| 23. |
Misuse of substances: There are a number of banned substances that can have potentially lethal effects on sperm production. Taking anabolic steroids, for example, to increase performance in sports such as weight lifting, can dramatically alter both the motility and the health of the spermatozoa. Other banned substances, such as cocaine, marijuana and heroin can reduce sperm production & may make a man infertile. |
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| 24. |
HGH Deficiency |
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| 3. |
How to Diagnosis the Disease?
For completes diagnosis of causes of Azoospermia one or more of the following tests may be required as:
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Complete Male Hormone Profile: this profile includes all the male hormone tests which affect testicular development, growth & other genital organ development as well as genital functions. L.h., f.s.h., testosterone, prolactins, thyroids test, |
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| 2. |
Antisperm Antibody |
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Usg or Doppler Study of Scrotum & Testis |
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Semen Fructose Ssensitivity |
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semen fructose |
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Fine Needle Testicular Biopsy of the Testis to look for Evidence of Spermatogenesis & Testicular Structure. |
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Human Sperm-Zona Pellucida Binding Ratio |
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Human Sperm-Zona Pellucida Pentration Test |
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Genetic Studies |
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Fnac Ttestis |
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Egg Penetration Test |
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Molecular Genetic Studies Done in Some Special Cases |
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Chromosome Analysis i.e. Karyotype (Chromosome Analysis) |
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Assessment of Androgen Receptor |
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Combined Pituitary Hormone Tests is Performed When Needed |
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Immunobead Test |
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Mri head, Hemogram, test for Systemic Diseases. |
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| 18. |
Olfactory Test is Done to Find out Kallman's Syndrome |
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| 4. |
What is the Spical Treatment in Saravana Hosptal for Compleate Cure of Azoospermia ?
We are the world famous doctors for curing azoopermia .we have treated many azoospermia patient in our hospital. all are getting excelent cure.
We are giving good compination medicine with out any side effect.
Our compination medicines give the rapid & gentie cure. Our group of medicines cover all the above mentioning diseases |
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Why the Saravana Hospital is Different When Compare the Other Hospitals ?
- We are filing patient cured reports.we have many patient cured reports in our hospital.
- Our compination medicine gives rapid cure.
- 100 % there is no any side effect. That’s why all foreigners are interested to take our medicines.
- We are removing the root of the cause & we are giving permenent cure.
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| 6. |
What is the Advantage of Taking Saravana Hospital Treatment?
100% homoeopathy medicine will not produce any side effect.
Our medicine gently act on your genes, immume system, all the functioning organisms like [brain, heart, liver, kidney, genital organs and thyroid etc.] Of your body so your hereditary diseases also eradicated from your body.
We are giving cource of treatment for a particular diseases.
If you’re a diabetic patient after taking our medicine sugar become normal.
All your choronic diseases will be cured after taking our medicines
If your cardiac patient don’t worry our medicine will reduce your rick complaint of coronary artery diseases.
If your cholestrol level is high above 200 & ldl is high after taking our medicine it is become normal.
Our medicine supply you the vetamines and minerals for maintaining your health.
If your having the complaint of hormonal imbalence aftertaking our medicine your hormone level will be normal.
All your mental cause of your diseases will |
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